Aspirin, prostaglandins, endoperoxides and platelets
نویسندگان
چکیده
منابع مشابه
Aspirin, platelets, and bleeding.
RECENT findings regarding the effect of acetylsalicylic acid on platelet function provide an interesting example of how astute clinical observation can lead to the discovery of basic physiologic and pathologic mechanisms. For many years Dr. Armand Quick had suspected that the ingestion of aspirin by hemophiliacs exaggerated their bleeding di-athesis. We were interested to find that some of the ...
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An important determinant of platelet-vessel wall interactions is the local balance of production of endothelial prostacyclin (PGI2) and platelet thromboxane (TX) A2, labile eicosanoids with opposing effects on hemostasis. Disputed evidence suggests that platelet-derived prostaglandin endoperoxide intermediates may be utilized as substrates for vascular PGI2 synthesis. Using several different ap...
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Prostaglandins not only have a role in inflammation, but may also be involved as mediators in the immune response. Drugs which affect prostaglandin synthesis may therefore be potential tools with which to modulate disturbed immunity. These possibilities are discussed with reference to immunity in leprosy, and in particular reversal reactions.
متن کاملAspirin, platelets, and thrombosis: theory and practice.
“D OES ASPIRIN PREVENT heart attacks?” The question is asked by both patients and physicians who wonder how a pill for headaches could influence a lethal vascular event. Today, a wealth of evidence shows that aspirin does, indeed, prevent heart attacks and related thrombotic disorders such as strokes.’ Performed over more than two decades, the pertinent studies range from clinical epidemiology ...
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Introduction: Cardiovascular disease is one of the most common diseases in the world. In this account, atherosclerosis is one of the main cause’s heart attacks. Coagulation activity of platelets plays an important role in atherosclerotic plaque formation, thrombosis formation and cardiovascular diseases. Aspirin is the most commonly drugs which used as anti-platelet function to prevent and trea...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/253088a0